ABSTRACT
To compare the nephrotoxic effects of two aminoglycosides namely, gentamycin and tobramycin on rabbits. Comparative study. Allama Iqbal Medical College Lahore, from January 2010 to December 2010. The serum levels of creatinine and electrolytes [sodium and potassium] were measured in different groups of rabbits [control group-A, gentamycin group B and tobramycin-group C]. Rabbits in group B and C received laboratory diet and 32 mg/kg/day of gentamycin and tobramycin were given through intramuscular [IM] route twice daily for 7 days. Blood samples were collected on day 1, 10, 16, and 22 of drug administration. Each rabbit of all groups was sacrificed on 22[nd] day of experiment. Kidneys were removed and histological examination of the 4 components of the renal tissue [glomeruli, tubules, blood vessels and interstitial tissue] was carried out. Level of serum creatinine was significantly increased in both experimental groups [B and C] as compared to the control group A. On the other hand, level of serum sodium was insignificantly increased in groups B and C, whereas level of serum potassium was significantly decreased in groups of rabbits receiving gentamycin and tobramycin as compared to control group. There was no significant difference in nephrotoxicity between gentamycin and tobramycin
Subject(s)
Animals , Aminoglycosides/adverse effects , Gentamicins/toxicity , Gentamicins/adverse effects , Tobramycin/toxicity , Tobramycin/adverse effects , Creatinine , Electrolytes , Kidney/drug effects , RabbitsABSTRACT
Background: Lithium is used for acute mania or prevention of the recurrences of bipolar manic-depressive illness in adults. There is a close relationship between toxicity and blood levels of sodium and potassium
Material and Methods: This study was carried out on 30 rabbits of mixed breed weighing 1 -2 kg. A lithium dose of 5mg/kg body weight/ day was given to rabbits for 22 days. Three blood samples were collected on 8th, 16th and 22nd days. Serum was separated and analyzed with flame photometer for lithium, sodium and potassium levels
Results: The level of serum lithium, sodium and potassium was significantly increased at 15th and 22nd day of administration of lithium carbonate
Conclusion: It is therefore concluded that concentration of lithium, sodium and potassium in serum must be determined. It is most important for family physicians who regularly treat patients receiving lithium as to how to monitor the safe use of drug